Common side effects include dizziness, low blood pressurelow blood potassiummuscle crampsand kidney problems.
The main difference between bumetanide and furosemide is in their bioavailability and potency. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.
In the first stage of synthesis, it undergoes sulfonylchlorination by chlorosulfonic acid, forming 4-chlorochlorosulfonylbenzoic acid, which is further nitrated with nitric acid to 4-chlorochlorosulfonylnitrobenzoic acid.
Reacting this with ammonia gives 5-aminosulfonylchloronitrobenzoic acid, which when reacted with sodium phenolate is transformed into 5-amino-sulfonylnitrophenoxybenzoid acid. Reduction of the nitro group in this product by hydrogen using a palladium on carbon catalyst gives 3-aminoaminosulfonyl- bumetanid fogyás acid.
Finally, reacting this with butyl alcohol in the presence of sulfuric acid gives the desired bumetanide. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizureswhich fogyás aludni often are not responsive to traditional GABA-targeted treatment, such as barbiturates.
Bumetanide is therefore under evaluation as a prospective antiepileptic drug.